Volume 7, Issue 5, October 2019, Page: 148-153
Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy
Atsushi Miyosh, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Hiroki Koga, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Satomi Nakamura, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Hiroaki Nakamura, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Kohei Yamada, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Hiroshi Kubo, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Masatsugu Hiraki, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Osamu Ikeda, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Toshiya Tanaka, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Kenji Kitahara, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Seiji Sato, Department of Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan
Hirokazu Noshiro, Department of Surgery, Faculty of Medicine, Saga University, Saga, Japan
Received: Aug. 17, 2019;       Accepted: Sep. 12, 2019;       Published: Sep. 26, 2019
DOI: 10.11648/j.js.20190705.17      View  227      Downloads  73
Background: The etiology, treatment and prevention of Nonalcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD) remain largely unknown. We aimed to elucidate the risk factors for NAFLD after PD and investigate the nutritional effects of zinc medication. Methods: We retrospectively examined 109 patients who underwent PD between 2013 and 2017. We diagnosed the postoperative NAFLD using CT attenuation at six months later. We identified the risk factors for postoperative NAFLD among perioperative factors and analyzed the nutritional effect of zinc medication at six months after surgery. Results: We diagnosed 27 patients with NAFLD after PD. A univariate analysis showed that pancreas cancer (p = 0.029), operative time (p = 0.008), blood loss (p = 0.034), postoperative diarrhea (p < 0.001) and zinc medication (p < 0.001) were associated with postoperative NAFLD. A multivariate analysis demonstrated that zinc medication was the most important factor for the prevention of NAFLD after PD. All patients who received zinc also took pancreatic enzyme simultaneously and showed a significantly lower rate of body weight loss than in patients without zinc at six months after PD (p = 0.041). These patients showed a significantly higher total cholesterol level (p = 0.006) and higher serum zinc level (p<0.001). Furthermore, significantly fewer cases of postoperative NAFLD were noted among the patients who received zinc than among those who did not receive it (5.7% vs 33.8%: p = 0.001). Conclusion: These results suggest that zinc administration might improve the postoperative nutritional status and prevent NAFLD after PD.
Pancreatoduodenectomy, Nonalcoholic Fatty Liver Disease, Zinc
To cite this article
Atsushi Miyosh, Hiroki Koga, Satomi Nakamura, Hiroaki Nakamura, Kohei Yamada, Hiroshi Kubo, Masatsugu Hiraki, Osamu Ikeda, Toshiya Tanaka, Kenji Kitahara, Seiji Sato, Hirokazu Noshiro, Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy, Journal of Surgery. Vol. 7, No. 5, 2019, pp. 148-153. doi: 10.11648/j.js.20190705.17
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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