Volume 8, Issue 2, April 2020, Page: 71-75
Ovarian Conservation in Patients with Early Stage Endometrial Carcinoma (EC) as a Safe Alternative to Oophorectomy
Walid A. Abdelsalam, Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Mohamed Fathy Abohashim, Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Doaa Mandour, Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Taha A. Baiomy, Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Ibrahim Heggy, Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Received: Feb. 25, 2020;       Accepted: Mar. 6, 2020;       Published: Apr. 17, 2020
DOI: 10.11648/j.js.20200802.16      View  90      Downloads  48
Background: Premenopausal females having early-stage EC have a favorable prognosis. The guidelines of surgical treatment of EC have not been modified and it consists of total hysterectomy, bilateral salpingo-oophrectomy, pelvic and para-aortic lymphadenectomy, regardless of patients’ age or EC stage. The drawbacks of performing bilateral BSO are induction of surgical premature menopause which subsequently disturbs physical and psychosexual life in addition to increasing risk of diseases of the cardiovascular system and bone fractures. The aim of our study was to demonstrate if performing BSO in premenopausal females patients with early stage EC had survival benefits and improving long-term outcomes or not. Patients and methods; we included sixty EC patients and we have performed ovarian conservation in 30 (50%) of them, and performed BSO in the remaining 30 patients we have followed our patients for 5 years from December 2014 to December 2019. Results: Age of patients with ovarian conservation was younger than patients with BSO (p=0.032), have smaller tumor size (p=0.02), higher degree of tumor differentiation (p=0.025), less incidence of myomertrial invasion (p=0.004), less liability of lymphovascular invasion (p=0.001), more liability to endometrioid histopathological subtype (p=0.003), and earlier stage (p=0.009) than patients with BSO. There were no significant differences between both studied groups regarding recurrence of the tumor, recurrence free survival and overall survival rates. Conclusion: The current study tried to highlight the benefits of a more conservative approach by ovarian preservation in surgical management and staging of EC patients diagnosed in the early stage in young premenopausal women.
Endometrial Cancer, Conservation of Ovaries, Survival
To cite this article
Walid A. Abdelsalam, Mohamed Fathy Abohashim, Doaa Mandour, Taha A. Baiomy, Ibrahim Heggy, Ovarian Conservation in Patients with Early Stage Endometrial Carcinoma (EC) as a Safe Alternative to Oophorectomy, Journal of Surgery. Vol. 8, No. 2, 2020, pp. 71-75. doi: 10.11648/j.js.20200802.16
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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