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Volume 8, Issue 6, December 2020, Page: 184-189
Difficult to Heal Wounds Intralesional Insulin Therapy Trial
Neide Kalil Gaspar, Departament of Dermatology, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil
Antonio Pedro de Andrade Gaspar, Departament of Dermatology, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil
Received: Jan. 14, 2020;       Accepted: Feb. 7, 2020;       Published: Nov. 9, 2020
DOI: 10.11648/j.js.20200806.13      View  34      Downloads  15
Abstract
Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.
Keywords
Wound Healing, Insulin, Growth Factor Wounds and Injuries, Difficult Wound Healing, Insulin Therapy, Growth Factors
To cite this article
Neide Kalil Gaspar, Antonio Pedro de Andrade Gaspar, Difficult to Heal Wounds Intralesional Insulin Therapy Trial, Journal of Surgery. Vol. 8, No. 6, 2020, pp. 184-189. doi: 10.11648/j.js.20200806.13
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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