Volume 4, Issue 2-1, March 2016, Page: 20-26
Age - Related Gastric Changes
Aly Saber, Department of general Surgery, Port-Fouad General Hospital, Port-Fouad, Port-Said, Egypt
Emad K. Bayumi, General Surgery, Crimean Medical Academy Named after S.I. Georgiesky of Crimea Federal University, Crimea, Russia
Received: Oct. 17, 2015;       Accepted: Oct. 18, 2015;       Published: Jan. 13, 2016
DOI: 10.11648/j.js.s.2016040201.15      View  5168      Downloads  191
Aging is a universal process with progressive loss of function accompanied by decreasing fertility and increasing mortality and disability. There are several mechanisms to underlie the primary aging process and probably contribute to age-related changes in adaptive responses. These mechanisms are oxidative stress, mitochondrial theory, telomeres and cellular senescence, apoptosis and genetic mechanism. There are many physiological changes with aging process including blood pressure, temperature, fever, and composition of body fluids. Age-related changes in bioavailability may be secondary to changes in absorption or gut wall and hepatic metabolism. The stomach lining's capacity to resist damage decreases with age due to alteration of the gastric defense mechanisms and decreased mucosal blood flow. Normal aging is associated with age-related changes in motor function of the various parts of the gastrointestinal tract such as transit time and gastric emptying. The incidence of many gastrointestinal dysfunctions increases with advancing age that is associated with alterations in the structural and functional integrity of the gastrointestinal tract. The structural changes include mucosa, muscular coat and blood flow. The clinical significance of functional and structural gastric changes may all impact upon gastrointestinal adverse effects and how older people tolerate medicines. Understanding how the upper gastrointestinal tract changes with advancing age could allow interventions that lead to more appropriate prescribing for older people, potentially reduce adverse effects, increase compliance with treatment regimens, and may allow older people to take medications that they would not otherwise tolerate.
Stomach, Changes, Functional, Structural, Aging
To cite this article
Aly Saber, Emad K. Bayumi, Age - Related Gastric Changes, Journal of Surgery. Special Issue: Gastrointestinal Surgery: Recent Trends. Vol. 4, No. 2-1, 2016, pp. 20-26. doi: 10.11648/j.js.s.2016040201.15
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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