Volume 5, Issue 3-1, May 2017, Page: 33-38
Evaluation of the Effect of the Blood Stopper; Ankaferd in Management of Post Laparoscopic Cholecystectomy Liver Bed Bleeding
Emad K. Bayumi, Researcher PhD General Surgery, Medical Academy Named After S. I. Georgiesky of Crimea Federal University, Crimea, Russia
Aly Saber, Department of Surgery, Port-Fouad General Hospital, Port-Said, Egypt
Leonie Sophia Van Den Hoek, Msc Researcher Health Psychology, Liberty International University, Wilmington, USA
Received: Jan. 29, 2017;       Accepted: Feb. 3, 2017;       Published: Feb. 28, 2017
DOI: 10.11648/j.js.s.2017050301.17      View  2875      Downloads  74
Introduction: The incidence of bleeding complications during laparoscopic cholecystectomy remains a frequent reason for conversion. Ankaferd Blood Stopper is a unique medicinal plant extract that has historically been used as a hemostatic agent and has been approved for the management of external hemorrhage and dental surgery bleeding. The aim of this study was to evaluate the effect of Ankaferd as a blooding stopper; in the management of liver bed bleeding in post laparoscopic cholecystectomy. Patients and Methods: A total of 120 patients; 60 for each group; group A (laparoscopic cholecystectomy with cauterization of gallbladder bed of the liver) and group B (laparoscopic cholecystectomy with application of Ankaferd drops by laparoscopic injector into gallbladder bed). End points: The primary end point of the study was measurement of the intraoperative bleeding as a result of application of both techniques; ankaferd instillation and cauterization of gallbladder bed of the liver. The secondary end points were estimation of the amount and characteristics of postoperative discharge till removal of drains, length of hospital stay and postoperative wound infection. Results: The operative time in group A was 85±34.5 minutes while in group B, it was 56±20.5 minutes. The mean amount of intraoperative bleeding was 58.1±29.97 ml and 37±14.47 ml in group A&B respectively. The mean amount of postoperative fluid drainage was 41.75±12.9 ml in group A while in group B was 30±6.75 ml and the hospital stay, It was 51.6±15.35 hours for patients of group A versus 31.8 ±8.5 hours for patients of group B respectively with significant distribution {P ≤ 0.001}. Conclusion: Ankaferd rapidly achieves hemostasis allowing surgeon to control bleeding properly and therefore the amount of operative bleeding, the operative time and the amount of postoperative fluid discharge on using ankaferd is statistically reduced.
Laparoscopic Cholecystectomy, Bleeding, Liver Bed, Ankaferd
To cite this article
Emad K. Bayumi, Aly Saber, Leonie Sophia Van Den Hoek, Evaluation of the Effect of the Blood Stopper; Ankaferd in Management of Post Laparoscopic Cholecystectomy Liver Bed Bleeding, Journal of Surgery. Special Issue: Minimally Invasive and Minimally Access Surgery. Vol. 5, No. 3-1, 2017, pp. 33-38. doi: 10.11648/j.js.s.2017050301.17
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Saber A, Abu-Elela ST, Shaalan KM, Al-Masry AR Preoperative Prediction of the Difficulty of Laparoscopic Cholecystectomy. J Surg Surgical Res (2015), 1 (1): 015-018.
Khan MW, Aziz MM. Experience in laparoscopic cholecystectomy. Mymensingh Med J. 2010; 19: 77–84.
Lengyel BI, Azagury D, Varban O, Panizales MT, Steinberg J, Brooks DC, et al. Laparoscopic cholecystectomy after a quarter century: why do we still convert? Surg Endosc. 2012; 26: 508–13.
Ballal M, David G, Willmott S, Corless DJ, Deakin M, Slavin JP. Conversion after laparoscopic cholecystectomy in England. Surg Endosc. 2009; 23: 2338–44.
Harboe KM, Bardram L. The quality of cholecystectomy in Denmark: outcome and risk factors for 20, 307 patients from the national database. Surg Endosc. 2011; 25: 1630–41.
Goker H, Haznedaroglu IC, Ercetin S, et al. Haemostatic actions of the folkloric medicinal plant extract, Ankaferd Blood Stopper. J Int Med Res. 2008; 36: 163–70.
Mevlut Kurt, Ibrahim Koral Onal, Meral Akdogan, Murat Kekilli, Mehmet Arhan, Abdurrahim Sayilir, Erkin Oztas, Ibrahim Celalettin Haznedaroglu. Ankaferd Blood Stopper for controlling gastrointestinal bleeding due to distinct benign lesions refractory to conventional antihemorrhagic measures. Can J Gastroenterol. 2010 Jun; 24 (6): 380–384.
Agrawal N, Singh S, and Khichy S. Preoperative Prediction of Difficult Laparoscopic Cholecystectomy: A Scoring Method. Niger J Surg. 2015 Jul-Dec; 21 (2): 130–133.
Aly Saber and Emad N. Hokkam. Operative Outcome and Patient Satisfaction in Early and Delayed Laparoscopic Cholecystectomy for Acute Cholecystitis. Minimally Invasive Surgery. 2014 (2014); 162643: 1-4.
Takegami K, Kawaguchi Y, Nakayama H, Kubota Y, Nagawa H. Preoperative grading system for predicting operative conditions in laparoscopic cholecystectomy. Surg Today. 2004; 34: 331–6.
Orhan Bat. The analysis of 146 patients with difficult laparoscopic cholecystectomy. Int J Clin Exp Med. 2015; 8 (9): 16127–16131
Neri V, Ambrosi A, Di Lauro G, Fersini A, Valentino TP. Difficult cholecystectomies: validity of the laparoscopic approach. JSLS. 2003; 7: 329–33.
El-Labban G, Hokkam E, El-Labban M, Saber A, Heissam K, El-Kammash S. Laparoscopic elective cholecystectomy with and without drain: A controlled randomised trial. J Minim Access Surg. 2012 Jul; 8 (3): 90-2
Sato N, Yabuki K, Shibao K, Mori Y, Tamura T, Higure A, Yamaguchi K. RISK FACTORS FOR A PROLONGED OPERATIVE TIME IN A SINGLE-INCISION LAPAROSCOPIC CHOLECYSTECTOMY. HPB (Oxford). 2014 Feb; 16 (2): 177-82.
Zdichavsky M, Bashin YA, Blumenstock G, Zieker D, Meile T, Konigsrainer A. Impact of risk factors for prolonged operative time in laparoscopic cholecystectomy. Eur J Gastroenterol Hepatol. 2012; 24: 1033–1038.
Emran Ali Algadiem, Abdulmohsen Ali Aleisa, Huda Ibrahim Alsubaie, Noora Radhi Buhlaiqah, Jihad Bagir Algadeeb, Hussain Ali Alsneini. Blood Loss Estimation Using Gauze Visual Analogue. Blood Loss Estimation Using Gauze Visual Analogue. Trauma Mon. 2016 May; 21 (2): e34131
Schorn MN. Measurement of blood loss: review of the literature. J Midwifery Womens Health. 2010; 55 (1): 20–7. doi: 10.1016/j.jmwh.2009.02.014.
Suuronen S, Kivivuori A, Tuimala J, Paajanen H. Bleeding complications in cholecystectomy: register study of over 22 000cholecystectomies in Finland. BMC Surg. 2015; 15: 97.
Suuronen S, Koski A, Nordstrom P, Miettinen P, Paajanen H. Laparoscopic and open cholecystectomy in surgical training. Dig Surg. 2010; 27: 384–90.
Kaushik R. Bleeding complications in laparoscopic cholecystectomy: Incidence, mechanisms, prevention and management. Journal of Minimal Access Surgery 6.3 (2010): 59–65.
Caliskan K1, Nursal TZ, Yildirim S, Moray G, Torer N, Noyan T, Haberal MA. Hydrodissection with adrenaline-lidocaine-saline solution in laparoscopic cholecystectomy. Langenbecks Arch Surg. 2006 Aug; 391 (4): 359-63.
Sartelli Massimo, Catena Fausto, Biancafarina Alessia, Tranà Cristian, Piccardo Andrea, Ceccarelli Graziano, Tirone Giuseppe, Agresta Ferdinando, Di Giorgio Andrea, Catani Marco, Tricarico Fausto, Buonanno Maurizio, and Piazza Luigi. Use of Floseal Hemostatic Matrix for Control of Hemostasis During Laparoscopic Cholecystectomy for Acute Cholecystitis: A Multicenter Historical Control Group Comparison (The GLA Study Gelatin Matrix for Acute Cholecystitis). Journal of Laparoendoscopic & Advanced Surgical Techniques. December 2014, 24 (12): 837-841.
Seyfi Emir, İlhan Bali, Selim Sözen, Fatih Mehmet Yazar, Burhan Hakan Kanat, Sibel Özkan Gürdal, and Zeynep Özkan. The efficacy of fibrin glue to control hemorrhage from the gallbladder bed during laparoscopic cholecystectomy. Ulus Cerrahi Derg. 2013; 29 (4): 158–161.
Köckerling F, Schneider C, Reymond MA, Hohenberger W. [Controlling complications in laparoscopic cholecystectomy: diffuse parenchyma hemorrhage in the liver parenchyma] Zentralbl Chir. 1997; 122: 405–408.
Fujikawa T, Tada S, Abe T, Yoshimoto Y, Maekawa H, Shimoike N, Tanaka A. Is Early Laparoscopic Cholecystectomy Feasible for Acute Cholecystitis in the Elderly? Journal of Gastroenterology and Hepatology Research 2012; 1 (10): 247-251
Evangelou GN, Stathakos HP, Baltayiannis NE, Gonianakis GI. Argon coagulation in laparoscopic cholecystectomy. Surg Endosc. 1996 Apr; 10 (4): 414-7.
Haznedaroglu BZ, Beyazit Y, Walker SL, Haznedaroglu IC. Pleiotropic cellular, hemostatic, and biological actions of Ankaferd hemostat. Critical Reviews in Oncology/Hematology 83 (2012) 21–34
Kurt M, Akdogan M, Onal IK, et al. Endoscopic topical application of Ankaferd Blood Stopper for neoplastic gastrointestinal bleeding: a retrospective analysis. Dig Liver Dis 2010; 42: 196–9.
bawahab ma, abd el maksoud wm, alsareii sa, al amri fs, ali hf, nimeri a, al amri am, assiri aa, abdul aziz mi. Drainage vs. Non-drainage after cholecystectomy for acute cholecystitis: a retrospective study. J biomed res. 2014 may; 28 (3): 240–245
Erhan Aysan, Hasan Bektas, Feyzullah Ersoz, Serkan Sari, Arslan Kaygusuz, and Gulben Erdem Huq. Ability of the ankaferd blood stopper® to prevent parenchymal bleeding in an experimental hepatic trauma model. nt J Clin Exp Med. 2010; 3 (3): 186–191.
Satar NY, Akkoc A, Oktay A, Topal A, Inan K. Evaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in rats. Blood Coagul Fibrinolysis. 2013 Jul; 24 (5): 518-24.
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